MacHall is, beyond a shadow of a doubt, my favorite web comic I've ever found. If you're a college kid, or even if you have any sense of humor at all, you owe it to yourself to check this out.
Penny Arcade is some high quality gamer humor. Some of it'll probably go over a lot of people's heads. So, unless you're REALLY into gaming, don't expect to see the humor in all of it. Nonetheless, there is some seriouly high-quality humor here, I laughed my ass off.
SinFest is a reliable way to laugh yourself stupid for a few hours. Slick, Monique, God, the Devil and more.
College Roomies from Hell isn't as much college humor as you'd think from the name. It's mostly slapsticky stuff, but it's really hilarious and another place where I've lost days of my life reading and re-reading the archives.
I just stumbled across a link to Bigger than Cheeses and it is one of the luckiest things I've ever done. The later comics are absolutely HILARIOUS. Do yourself a favor and give it a click.
Linux gives us the power we need to crush those who oppose us.
Funny, funny stuff.
Gotta love obscure videogame humor. The origional video that brought us the phrase "all your base are belong to us." Gotta love poorly translated Japanese videogames from the eighties.
The Belfry Comics Index is an absolutely massive comic listing, indexed by how often they update. They've also rated the comics by their content, so you won't accidentally stumble into some animated porn. Or so you can find your animated porn easier, whichever.